ESTRO35 Programme Book

SATURDAY 30 APRIL 2016

14:30 > Do we need randomised clinical data to justify the use of SABR for primary and oligometastatic cancer? Speaker: F. Mcdonald (UK) 14:50 > Pre-clinical and clinical data on the radiobiological mechanism for the efficacy of SABR Speaker: M. Brown (USA) 15:10 > Technical developments in high precision radiotherapy: a new era for clinical SABR trials? Speaker: M. Aznar (Denmark)

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15:30 > Radiation dose-volume effects for liver SBRT

M. Miften (USA), Y. Vinogradskiy, V. Moiseenko, J. Grimm, E. Yorke, A. Jackson, W.A. Tomé, R. Ten Haken, N. Ohri, A.M. Romero, K.A. Goodman, L.B. Marks, B. Kavanagh, L.A. Dawson

OC-0097

Symposium TUMOUR TARGETING - CONSIDERING NORMAL TISSUE BIOLOGY 14:30 - 15:45 | LONDRA Stem cells are thought to be major players in the response of normal tissue and tumours to (chemo-) radiation. In this symposium recent developments in the field of (cancer) stem cell science and genetics are combined. Using several techniques such as the stem cell culturing as organoids or basal cell lay- ers derived from biopsies enabled the study the molecular cues involved in the (patient specific) treat- ment response. Mathematical modelling of signalling network, (epi)genetic changes and response analysis of specific stem/progenitor cells involving known and less well know cues are discussed in the light of potential modification, optimisation and personalisation of radiotherapy. Chair: R. Coppes (The Netherlands) Co-chair: M. Mangoni (Italy) 14:30 > Organoids, a disease and patient specific in vitro model system Speaker: R. Vries (The Netherlands) 14:48 > The role of ATM and p53 in normal tissue radiation response Speaker: D. Kirsch (USA) 15:06 > Radiation sensitivity of human skin stem cells: dissecting epigenetic effects of radiation Speaker: M. Martin (France) 15:24 > A radiation systems biology view of radiation sensitivity of normal and tumour cells Speaker: K. Unger (Germany)

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SCIENTIFIC PROGRAMME | PROGRAMME AND EXHIBITION GUIDE

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