ESTRO35 Programme Book

TUESDAY 3 MAY 2016

09:45 > GWAS, SNPs and normal tissue toxicity for personalised radiation oncology Speaker: C. West (UK)

SP-0580

10:00 > Integrative data analysis for PRO Speaker: M.A. Gambacorta (Italy)

SP-0581

10:15 > Gene signatures predict loco-regional control after postoperative radio- chemotherapy in HNSCC S. Schmidt (Germany), A. Linge, F. Lohaus, V. Gudziol, A. Nowak, I. Tinhofer, V. Budach, A. Sak, M. Stuschke, P. Balermpas, C. Rödel, M. Avlar, A.L. Grosu, A. Abdollahi, J. Debus, C. Belka, S. Pigorsch, S.E. Combs, D. Mönnich, D. Zips, G.B. Baretton, F. Buchholz, M. Baumann, M. Krause, S. Löck Symposium THE TUMOUR IN 3D: THE ROLE OF TUMOUR MICROENVIRONMENT 09:15 - 10:30 | LONDRA The microenvironment is an integral part of normal and tumour tissue development, homeostasis and 3D architecture. For the generation of clinically relevant data, we need to take these characteristics into consideration. Recent observations using 3D cell culture models provide evidence that the cellular response to irradiation is similar to the effects seen in tissues and different from conventional 2D cell cultures. In this symposium, we will show the advantage of 3D cell culture models over 2D and how they can be used for (i) testing tumor and normal cell radiation responses with and without chemo- therapy/novel molecular drugs and (ii) expansion of stem cells for therapy. Further, we will demonstrate the differential impact of hypo- and hyperfractionation radiotherapy on the immune system.

OC-0582

Chair: N. Cordes (Germany) Co-chair: G.L. Gravina (Italy)

09:15 > Relevance of 3D cultures to address radiation response and novel RT combination strategies Speaker: N. Cordes (Germany)

SP-0583

09:33 > The potential of normal tissue organoid cultures Speaker: R. Coppes (The Netherlands)

SP-0584

09:51 > The impact of a novel 3D cell culture model of glioblastoma on radiation and drug-radiation responses Speaker: N. Gomez-Roman (UK)

SP-0585

10:09 > Radiotherapy supports tumour-specific immunity Speaker: M. Van den Broek (Switzerland)

SP-0586

SCIENTIFIC PROGRAMME | PROGRAMME AND EXHIBITION GUIDE

151