Gynae BT 2017

Inter-rater reliability of CTCAE morbidity assessment

Atkinson et al. Qual Life Res 2012 N=393 patients, mixed cancer type CTCAE assessed by 2 independent physicians within ~1h

Results in symptomatic patients 15-43% agreement

51-70% 1 grade differences 1-18% 2 grades differences

CTCAE agreement between 2 physicians is moderate at best!

The lower the CTCAE grading, the more variation between physicians is observed. Disagreement mainly between G0/G1/G2. Chinnachamy et al. Jpn J Clin Oncol 2013