Haematology 2018

Heart failure after HL (1st event) 91 cases and 278 controls nested in cohort of 2,617 Dutch five-year survivors of HL treated between 1965 and 1995

• Anthracycline-containing chemotherapy increased HF rate by a factor of 2.83 (95%CI: 1.43-5.59) with no significant interaction with mean left ventricular dose (p=0.09). • No dose-effect relationship for anthracycline dose • No interaction with general risk factors CVD

Van Nimwegen et al., Blood 2017