Haematology 2018

2.5

Cardiovascular disease after therapy for HL: A detailed analysis of 9 collaborative EORTC-LYSA trials 2 The mean heart radiation dose and the cumulative dose of anthracyclines were significant predictors of CVD, with an increase in hazard rate of 1·5% (95% CI: 0·6–2·4%) per 1 Gy increase in mean heart dose and 7·7% (95% CI: 2·1–13·7%) per 50 mg/m2 increase in cumulative anthracycline dose. 1 1.5 0 5 10 15 20 25 30 35 40 Hazard ratio

Increase in mean heart dose (Gy)

2 Hazard ratio A 2.5 3

2 Hazard ratio B 2.5 3

1.5

1.5

1

1

0

5

10

15

20

25

30

35

40

0

100

200

300

400

500

Increase in mean heart dose (Gy)

Increase in cumulative dose of anthracyclines (mg/m 2 )

Maraldo et al, Lancet Hemat 2015

B

3