Haematology 2018

Correlation of dose and efficacy Cytostatic drugs in vitro

1.0

0.1

Methotrexate Vincristine Ara-C

0.01

Cyclophosphamide

0.001

BCNU

Carboplatinum

(breast cancer)

0.0001

Thiotepa

Surviving Fraction MCF7

Melphalan

0.00001

2 4 6 8 10 Dose (multiples of IC 90 )