Haematology 2018

HD8 in early unfavorable HL Long-term outcome

1.0

╵

╵

1.0

╵

╵

╵ ╵ ╵ ╵╵ ╵╵╵╵╵ ╵╵╵ ╵╵ ╵╵╵ ╵╵╵ ╵╵ ╵╵╵╵ ╵ ╵╵╵ ╵ ╵╵ ╵ ╵╵╵ ╵╵ ╵╵ ╵╵ ╵ ╵╵╵╵ ╵╵ ╵ ╵╵ ╵╵ ╵╵╵╵╵ ╵ ╵╵╵ ╵ ╵╵ ╵ ╵╵ ╵╵╵╵╵╵ ╵╵╵╵ ╵ ╵╵╵ ╵╵ ╵╵ ╵ ╵ ╵╵ ╵ ╵╵ ╵ ╵╵╵╵╵╵╵╵╵╵╵╵╵╵╵╵╵╵╵ ╵╵╵╵╵ ╵╵╵╵╵╵╵ ╵ ╵╵╵╵╵ ╵╵╵╵ ╵╵╵

╵ ╵╵╵╵ ╵╵╵ ╵ ╵ ╵╵╵╵ ╵╵ ╵ ╵╵╵╵╵╵╵╵╵╵ ╵ ╵╵ ╵╵╵ ╵╵╵╵ ╵╵╵╵╵╵ ╵╵╵╵ ╵ ╵╵╵╵ ╵╵ ╵╵╵╵╵ ╵╵ ╵ ╵╵ ╵ ╵╵ ╵╵ ╵╵╵╵ ╵╵╵ ╵

OS

PFS

╵╵ ╵╵ ╵ ╵╵ ╵ ╵╵╵╵╵

0.9

0.9

╵

╵╵╵ ╵╵╵ ╵╵╵╵╵╵╵╵ ╵ ╵╵ ╵╵╵╵╵╵╵╵╵

╵ ╵╵ ╵ ╵╵ ╵╵╵╵╵╵╵╵╵╵╵╵╵╵╵ ╵

0.8

╵ ╵ ╵

╵ ╵ ╵╵╵ ╵╵╵ ╵╵╵

╵ ╵

0.8

╵╵ ╵╵╵╵╵ ╵╵╵╵╵╵ ╵ ╵╵╵╵ ╵ ╵ ╵ ╵╵╵╵╵╵ ╵

╵╵ ╵╵╵╵╵╵╵ ╵╵╵╵ ╵╵╵╵╵╵╵╵╵╵╵ ╵

╵╵╵╵╵ ╵╵╵╵╵

0.7

╵╵ ╵ ╵ ╵╵╵ ╵╵ ╵

15 year estimate [95%-CI]

0.7

╵╵

╵╵

╵╵╵ 15 year estimate [95%-CI] EF: 80.5% [76.7% to 84.3%] IF: 82.4% [78.7% to 86.0%] diff: 1.8% [-3.4% to 7.1%] Hazard Ratio 0.88 [0.66 to 1.16] Median observation time 174 months ╵╵╵ ╵╵ ╵╵ ╵ ╵╵╵╵╵ ╵ ╵╵╵ ╵╵ ╵ ╵ ╵ ╵╵╵ ╵╵ ╵ ╵ ╵ ╵ ╵ ╵ ╵╵ ╵ ╵ ╵ ╵

0.6

EF:

72.7% [68.2% to 77.2%]

0.6

0.5

0.5

IF:

73.8% [69.2% to 78.3%]

0.4 PFS rate

0.4

diff: 1.1% [-5.3% to 7.5%] Hazard Ratio 0.98 [0.76 to 1.25] Median observation time 153 months

0.3

0.3

Overall Survival rate

0.2

0.2

0.1

0.1

EF

IF

0.0

EF

IF

0.0

0 12 24 36 48 60 72 84 96 108 120 132 144 156 168 180

0 12 24 36 48 60 72 84 96 108 120 132 144 156 168 180

Time [months]

Time [months]

532 517 492 472 442 418 395 362 333 307 282 255 228 209 183 152 532 512 487 466 437 401 364 330 312 285 255 228 200 176 157 134 Pts. at risk

532 523 511 499 477 461 445 424 405 381 354 326 300 273 244 203 532 531 518 507 490 461 433 410 391 367 346 319 291 260 228 197 Pts. at risk

Bröckelmann et al; EHA 2016