Haematology 2018

Constraints, why are they so difficult in lymphomas?

• The location of the target varies, may be located anywhere in the body • The doses that we need are much lower than in solid tumours • Acute toxicity is not a major problem • Most patients may expect to become long-term survivors • Late effects are a major issue • Even the low doses used for lymphoma treatment cause serious late effects, there is no safe dose level