Haematology 2018

But how to distinguish phenotype?

► Getting it right is important when looking prospectively at therapy, not prognosis ► The immunophenotype is not that good: ► CD10+ (about 1/3), Mum-1-: Almost all GCB ► CD10- (2/3) hard to distinguish ABC from GCB on immuno’s ► Bcl-6 is a difficult stain ► Discordance with mRNA (~20%) ► Conflicting IHC datasets ► Lunenberg project demonstrates poor correlation between centres (technical and interpretative)

Hans, C. P. et al. Blood 2004;103:275-282