Haematology 2018

The paradigm for study design….don’t change practice yet

R-CHOP

Biological and clinical stratification

R

DLBCL

R-CHOP+X

Ongoing X= Lenalidomide Ibrutinib Bortezomib Brentuximab Everolimus Tazemetostat More to come…

Can we practically deliver this design in phase III with so many agents?

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