Haematology 2018
The paradigm for study design….don’t change practice yet
R-CHOP
Biological and clinical stratification
R
DLBCL
R-CHOP+X
Ongoing X= Lenalidomide Ibrutinib Bortezomib Brentuximab Everolimus Tazemetostat More to come…
Can we practically deliver this design in phase III with so many agents?
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