Haematology 2018

Understanding T- cell immune check-points in the tumour microenvironment and reversing immunosuppression

Antigen Presenting Cell

T Cell

?

B7-H3 / CD276

B7-H4 / B7X / B7S1 / VTCN1

?

B7DC / PDL2 / CD273 B7H1 / PD-L1 / CD274

PD-1 / PDCD1 / CD279 ?

Inhibitory receptors

CD28 CTLA-4 / CD152

B7.1 / CD80 B7.2 / CD86

MHC

T Cell Receptor

LAG-3 / CD223

Activatory receptors

Antigen

GITR / AITR / TNFRSF18

GITRL / AITRL / TNFSF18

OX40L / gp34 / CD252

OX40 / ACT-135 / TNFRSF4 / CD134 CD137 / 4-1BB / ILA / TNFRSF9

CD137L / 4-1BBL / TNFSF9

ICOS / CD278/ AILIM / CRP-1

ICOSL / B7H2 / GL50 / B7RP1 / CD275