Haematology 2018

Lesson learnt from immune check-point inhibition in solid tumours

Anti-PD1

Anti-CTLA-4

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Hard wired

Induced resistance

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Targets CD28 pathway

Targets TCR pathway

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Works during priming

Works on exhausted T cells

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Does not expand clonal diversity

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Primarily effects CD8 T cells

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Primarily effects CD4 T cells

Does not move T cells into tumours

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Can move T cells into Tumour

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Responses usually rapid

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Responses often slow

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Disease recurrence after responses significant

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Disease recurrence after response rare