Hematological Malignancies
AETHERA PFS per Investigator
HR = 0.50 [95% CI (0.36, 0.70)] Median BV = NE (–, –); Placebo = 15.8m (8.5, –) 24-month PFS rate BV = 65%; Placebo = 45%
10 20 30 40 50 60 70 80 90 100
Stratified Hazard Ratio
N Events (Months) Median 164 89 15.8 165 60 --
Percent of Subjects Free of PD or Death 0 Placebo+BSC BV+BSC
0.50
0
4
8
12
16 20
24 28
32
36 40
44 48
52
Time (Months)
N at Risk (Events) Pla+BSC BV+BSC
164 (0) 113 (48) 92 (67) 83 (76)
77 (81) 71 (85)
61 (88) 45 (89)
28 (89) 40 (59)
23 (89) 13 (89) 33 (60) 16 (60)
3 (89) 4 (60)
3 (89) 3 (60)
0 (89) 0 (60)
165 (0) 149 (12) 133 (27) 122 (36) 111 (45) 103 (52) 90 (55) 62 (58)
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