Hematological Malignancies

Idelalisib is highly selective for PI3Kδ isoform

Class I PI3K isoform 1

Expression

Ubiquitous

Ubiquitous

Leukocytes

Leukocytes

nM

>20,000

1900

3000

8

EC 50

 Promising activity in relapsed / refractory (R/R) indolent non-Hodgkin lymphoma (iNHL) in a Phase I study 2

1. Lannutti BJ, et al. Blood 2011;117:591-4; 2. Flinn IW, et al. Blood 2014;123:3406-13 ;