Hematological Malignancies

Other inhibitors of PI3K

Class I PI3K Isoform

α

β

γ

δ

Ubiquitous

Ubiquitous

Leukocytes

Leukocytes

Expression

Insulin signaling Mutated in solid tumours

Platelet activation Neutrophil function Insulin signaling

Mast cell activation Innate immunity Immune tracking

B and T cell activation Fc receptor signaling

Idelalisib IPI-145 Copanlisib