Hematological Malignancies

• Dosoretz et al. treated 30 PBLs with RT alone 5 year-DFS: 53%; OS:63% Cumulative incidence of local recurrence: 14% No local failures if dose up to 50 Gy • Fairbanks et al. reported on 63 Stage IE PBLs 50 pts received RT alone, 10 CMT, 2 CT alone, 1 surgery alone Univariate analysis: improved 5-year DFS with CMT vs RT alone (90% vs 57%) Doses over 40 Gy improved OS • Bacci et al. 30 pts with localized PBL with 10 yrs follow-up 26 pts CT with anthracycline-chemo: 3 systemic relapses 4 RT only (30-45 Gy whole bone; 10-15 Gy boost): 1 local relapse DFS 88 % at 87 months mean follow-up Excellent cure rates with the addition of CT to RT Treatment: CMT as standard approach