Hematological Malignancies

Yttrium-90 Ibritumomab tiuxetan (Zevalin TM )

• Ibritumomab

Monoclonal antibody

– Murine monoclonal antibody parent of Rituximab

• Tiuxetan

Conjugated to

antibody, forming strong urea-type bond

Stable retention of 90 Y

Chelator

90 Y

• 90Y – Beta emitter