Hematological Malignancies

Primary CNS Lymphoma: A unique lymphoma entity

• Increasing incidence (immunocompetent, older) • PCNSL- Confined to brain (occasionally to eyes and CSF) • Systemic spread is very rare • Multi-centric in the brain in presentation and in relapse (unlike gliomas) • Resection is not associated with better outcome • May initially improve and even temporarily disappear with steroids (may mask a diagnosis) 5