Hematological Malignancies

PCNSL Epidemiology • Risk Factors

– Immunosuppression • Congenital (SCID, Wiskott-Aldrich Syndrome) • Acquired (HIV) – The risk of PCNSL in HIV patients is 3600-fold higher than general population – Up to 2/100 HIV infected persons develop PCNSL • Iatrogenic (Organ allograft recipients)