Hematological Malignancies

Primary CNS Lymphoma

• Type

• Clinical Features

• Mean age = 60 • Gender: men: women - 1:1 • 23% ocular involvement • 17% positive CSF cytology • Clinical features

• Primary

– Brain – Leptomeninges – Eye – Spinal cord

– 51% behavioral/personality – 28% hemiparesis – 13% seizure

• Metastatic

– Leptomeninges 4-11% – Epidural 3-5% – Brain 1%

• DLBCL histology

– ~85% Non-GC