Hematological Malignancies

RICOVER-60

6 x CHOP-14 + 36 Gy (Bulk, E)

RICOVER-60-no-RT

Held, JCO 2014l

8 x CHOP-14 + 36 Gy (Bulk, E)

CD20 + DLBCL Stage I-IV 61 - 80 years

Random 2x2 Factorial Design

6 x CHOP-14 + 36 Gy (Bulk, E) + 8 x Rituximab

8 x CHOP-14 + 36 Gy (Bulk, E) + 8 x Rituximab 6 x CHOP-14 + 36 Gy (Bulk, E) + 8 x Rituximab

RICOVER-60-no-RT: -3rd Amendment -Recruitment 08/2005 – 10/2007 -Number of Patients 166 -Median Observation 39 Months

Pfreundschuh, Lancet Oncol, 2008