Hematological Malignancies

Multivariate analysis of prognostic factors correlated with response to Zevalin for NHL • Analysis of 4 clinical registrational studies • Patients with extensive prior therapy (1-9 regimens), bulky disease, splenomegaly • Disease bulk (< 5 cm) correlated with overall response rate (89 patients ORR 90% (p<0.001) • Other unfavourable characteristics (high LDH, extranodal disease, splenomegaly, extensive prior therapy, elevated peripheral B cell count) that might have been expected to confer a reduced probability of response failed to do so

Czuczman et al Proc ASCO 2002