Hematological Malignancies

Understanding T- cell Immune Check-Points in the Tumour Microenvironment and Reversing Immunosuppression

T Cell

Antigen Presenting Cell

?

B7-H3 / CD276

B7DC / PDL2 / CD273 B7H1 / PD-L1 / CD274 B7-H4 / B7X / B7S1 / VTCN1

T Cell Receptor CD28 CTLA-4 / CD152 PD-1 / PDCD1 / CD279 ? ?

Inhibitory receptors

B7.1 / CD80 B7.2 / CD86

MHC

LAG-3 / CD223

Activatory receptors

Antigen

GITR / AITR / TNFRSF18

GITRL / AITRL / TNFSF18 OX40L / gp34 / CD252 CD137L / 4-1BBL / TNFSF9

OX40 / ACT-135 / TNFRSF4 / CD134 CD137 / 4-1BB / ILA / TNFRSF9 ICOS / CD278/ AILIM / CRP-1

ICOSL / B7H2 / GL50 / B7RP1 / CD275