Hematological Malignancies
EL4 model of T cell Lymphoma
** ++
100
Control 5x2Gy RT
75
EG7 model of T cell Lymphoma
3mg/kg R848 q1w
50
3mg/kg R848 q1w + 5x2Gy RT
Control 10Gy + 3mg/kg R848 q1w 10Gy + 3mg/kg R848 q1w + α CD8 mAb ***
25
100
Percent survival
0
75
0
20
40
60
Time after tumour implantation (days)
50
A20 model of B cell Lymphoma
25
** +
Percent survival
100
0
0
20
40
60
NT
Time after tumor implantation (days)
75
3 mg/kg R848 q1w 5x2Gy RT 5x2Gy RT + 3 mg/kg R848 q1w
50
25
Percent survival
0
0
20
40
60
Time after tumor implantation (days)
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