Hematological Malignancies

HL treatment changes since 1965

Chemotherapy

Radiotherapy

Trend: ↓ dose alkylating

Trend: ↓ RT target volumes, ↓ RT dose

<1980

MOPP(like) & single agents MOPP/ABVD; MOPPABV

<1980

Classical fields

1980-1995

1980-1995

Classical fields; IFRT

>1995 >2012

ABVD; MOPP-ABV; EBVP; BEACOPP >1995 Brentuximab-vedotin containing regimens >2006

IFRT

INRT; ISRT

MOPP: Mechlorethamine, vincristine, procarbazine, prednison ABVD: Doxorubicin, bleomycin, vinblastine, dacarbazine ABV: Doxorubicin, bleomycin, vinblastine BEACOPP: Bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednison

Hodgson, ASH educational 2011