Hematological Malignancies

Risk measures in late effect research • Standardized Incidence Ratio (SIR) = Observed / Expected numbers of events = Relative risk compared to general population - High SIR for rare event  low absolute risk • Absolute excess risk (AER) = Excess number of events beyond expected number / 10,000 persons/ year • Cumulative incidence = % developing event, accounting for death as a competing risk • Hazard ratio = RR for treatment A vs treatment B