Hematological Malignancies

Lung cancer after HL Joint effects of smoking and treatment

• Risks from smoking multiply risks from treatment • Smoking is the major cause of lung cancer (only 7 out of 222 cases were never smokers)

RR non/light smokers

RR smokers

No RT (< 5 Gy), no CT RT ( ≥ 5 Gy), no CT No RT (< 5 Gy), CT RT ( ≥ 5 Gy), CT

1.0 (ref) 7.2 (2.9-21.2) 4.3 (1.8-11.7) 7.2 (2.8-21.6)

6.0 (1.9-20.4) 20.2 (6.8-68) 16.8 (6.2-53) 49.1 (15.1-187)

Travis et al. JNCI 2002; 94:182