Hematological Malignancies

• Mediastinal radiotherapy increases mortality of CVD, esp. coronary artery disease (Boivin, Cancer 1992; 69:1241; Hancock, JAMA 1993; 270:1949; Swerdlow JNCI 2007; 99:206; Aleman JCO 2003; 21:3431) • Fewer studies examined CVD morbidity (Hull JAMA 2003; 290:2831; Aleman, Blood 2007; 109:1878; Glanzmann, Rad Oncol 1998; 46:51) • Increased mortality for > 25yrs • Also increased risk for valvular disease (Aleman, Blood 2007; Hull, JAMA 2003)