Hematological Malignancies

Literature cardiovascular disease after HL, II • Radiation dose-response? Only assessed in childhood cancer, childhood HL and breast cancer • Schellong PBC 2010 (childhood HL): Effect of prescribed mediastinal RT dose on risk (very small numbers per dose category) • Mulrooney BMJ 2009 (CCS): increased risk for prescribed doses ≥ 15 Gy • Dose to heart or cardiac substructures assessed in only two studies (Darby NEJM 2013; Tukenova JCO 2010) • Tukenova JCO 2010 (CCS): for all CVDs combined (n=32) association with average radiation dose to heart