Hematological Malignancies

Multivariable regression analysis

CRC

Transverse colon & rectum

Risk Factor

HR

95% CI

HR

95% CI

Treatment

Procarbazine No CT or CT without procarbazine CT, ≤ 4.2g/m 2 procarbazine CT, > 4.2g/m 2 procarbazine

1.0 1.7 2.7

Reference

1.0 1.8 3.6

Reference

0.7-4.4 1.4-5.2

0.6-6.0 1.5-8.6

Radiotherapy No infradiaphragmatic RT Infradiaphragmatic RT

1.0 1.8

Reference

1.0 2.2

Reference

1.0-3.2

1.0-4.7

Cox model adjusted for sex and age. HR = Hazard ratio; 95% CI = 95% confidence interval 4.2 g/m 2 procarbazine≈3x MOPP or 6 MOPP-ABV(D)