Hematological Malignancies

Characteristics (3)

• Prognosis:

– Early stage: highly curable – Advanced stage: multiply relapsing – Transformation to HG-NHL particularly TCR-DLBCL • 10 y risk 10-12% • 20 y risk up to 30% • Risk fs: advanced stage, spleen / abdominal presentation – Importance of Bx of every relapse + long FU – Death due to NLP is uncommon