Hematological Malignancies

Correlation of dose and efficacy Cytostatic drugs in vitro

1.0

0.1

Methotrexate Vincristine Ara-C

0.01

0.001

Cyclophosphamide Carboplatinum

BCNU

Surviving Fraction MCF7 (breast cancer) 0.0001

Thiotepa

Melphalan

0.00001

10

2

4

6

8

Dose (multiples of IC 90 )