Hematological Malignancies

FL: Reasons to initiate treatment

B-symptoms

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• Hematopoietic failure (Hb<11g/dl, granulocytes <1.500/µl, platelets <100.000 /µl) • Large tumor burden (3 areas >5 cm or 1 area >7.5 cm) • Rapid progression (increase of tumor mass >50% within 6 months) • Complications due to disease (pain, infarction of spleen, hyperviscosity syndrome, etc.) • No role for FLIPI, LDH, B2M, age, stage, or bone marrow involvement