ICHNO-ECHNO 2022 - Abstract Book

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ICHNO-ECHNO 2022

Figure 2

Conclusion Albeit limited by the small sample size, our preliminary observation of anti-tumor activity and tolerability of DUR in addition to CTX and radiation may warrant further investigations

PO-0151 Prognostic significance of immune inflammation biomarkers in 615 patients of oropharyngeal cancer

S. KASHID 1 , A. Budrukkar 2 , M. Swain 3 , A. Sasidharan 3 , S. Ghosh-Laskar 4 , V. Murthy 1 , T. Gupta 5 , K. Prabhash 6 , A. Patil 7 , S. Sinha 2 , A. Kumar 1 , J.P. Agarwal 8 1 Tata Memorial Hospital, Radiation Oncology, Mumbai, India; 2 Tata Memorial Hospital , Radiation Oncology, Mumbai, India; 3 Tata Memorial Hospital , Radiation Oncology , Mumbai , India; 4 Tata Memorial Hospital , Radiation Oncology , Mumbai, India; 5 Tata Memorial Hospital , Radiation Oncology, Mumbai , India; 6 Tata Memorial Hospital, Medical Oncology, Mumbai, India; 7 Tata Memorial Hospital, Pathology, Mumbai , India; 8 Tata Memorial Hospital, Radiation Oncology, Mumbai , India Purpose or Objective To evaluate role of pre-treatment immune inflammation markers in oropharyngeal squamous cell cancer (OPSCC) treated with definitive radiotherapy (RT). Materials and Methods Pre-treatment immune inflammation biomarkers including neutrophil to lymphocyte ratio (NLR), Platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and Onoderas`s prognostic nutritional index (PNI) were evaluated for correlation with clinical outcomes in OPSCC treated with radiotherapy. Kaplan Meir method was used for survival analysis, log rank test was used for univariate analysis and Cox regression method was used for multivariate analysis. Results Pre-treatment immune inflammation biomarkers of 615 OPSCC patient treated with RT from Jan 2013 to Dec 2017 were analysed. At median follow up for surviving patients of 53.9 months (IQR 27.7-65.2) 5 year overall survival (OS), local