ICHNO-ECHNO 2022 - Abstract Book

S106

ICHNO-ECHNO 2022

peristomal RIG infection as a complication is currently lacking. We evaluated the impact of our multi-speciality agreed protocol (use of prophylactic antibiotics, pre-procedure skin preparation and post-procedure washes) in reducing the rates of swab positive peristomal infection related to RIGs sited in patients undergoing treatment for HNC at our centre. Materials and Methods Within the HNC population in a large UK cancer centre, data on all consecutive patients in whom RIGs had been sited up to 1 year prior to our protocol implementation were collected retrospectively (Group A, n=49). Subsequently, following protocol implementation, data on patients in whom RIGs had been sited up to 1 year following protocol implementation was collected prospectively (Group B, n=42). Microbiologically confirmed peristomal infection rates between these two patient cohorts were compared. Statistically, t-test or chi squared test was used, where appropriate. Results The mean age of patient cohort in group A was 60.8 years (SE 1.6) versus 65.5 years (SE 1.5) and this difference was not significant (p 0.131). The implementation of protocol procedure resulted in a statistically significant reduction in frequency of positive swabs from the peristomal area within 60 days of RIG insertion (36.7% in group A vs 16.7% in group B; p 0.033) with odds ratio 0.344 (95% CI 0.127 – 0.934). However, there was no evidence to suggest that there was any delay in developing RIG-associated infections. The mean time to develop infection from the day of RIG insertion was 12.1 days in group A versus 11.8 days in group B (p 0.431). Conclusion Our study has demonstrated a statistically significant reduction in peristomal RIG-associated infection rates in HNC patients following the implementation of a multidisciplinary-agreed protocol. We would suggest that such a demonstrable clinical improvement will inevitably translate to further benefits including: a reduction in hospital stay, less treatment breaks, a reduction in alternative nosocomial infection exposure, promotion of patient quality of life and reducing the burden on existing strained hospital resources. Particularly in the era of the Covid-19 pandemic, the value of such factors cannot be overstated.

PO-0168 Quality of life of patients with locally advanced oral and oropharyngeal cancer

N. Trizna 1 , J. Kaliadzich 2

1 National Cancer Centre of Belarus, Outpatient Surgery, Minsk, Belarus; 2 National Cancer Centre of Belarus, Head and Neck Cancer, Minsk, Belarus

Purpose or Objective to study the quality of life of patients after surgical treatment of oral and oropharyngeal cancer.

Materials and Methods The quality of life of 31 patients with tumors of oral and oropharyngeal cancer was analyzed using the EORTC QLQ-30 and EORTC QLQ-H & N35 questionnaires.

Results Using the EORTC QLQ-30 questionnaire, an improvement in general health, emotional functioning, cognitive function, a decrease in the level of pain, the frequency of insomnia (p> 0.05) were revealed, which, taking into account the assessment of clinical significance according to K. Cocks et al. had a low degree of clinical significance of changes in the studied parameters for all scales, except for the insomnia scale corresponding to the average degree of clinical significance. But the statistically significant change in the fatigue scales (p <0.01) corresponded to a low degree of clinical significance, and a decrease in appetite (p <0.05) should be regarded as insignificant. Using the EORTC QLQ - H & N35 questionnaire showed a deterioration in some functions associated with the consequences of anticancer treatment, including impaired taste and odor perception (p <0.01), speech disorders (p <0.05), difficulties in public reception food (p <0.01), difficulties in social contacts (p <0.05), viscous saliva (p <0.05). Conclusion The study revealed positive changes in the quality of life of patients with oral and oropharyngeal cancer in the period from 4 to 6 months after the end of treatment, which indicates a gradual return to the initial level of vital activity and the need for regular monitoring of the quality of life of patients in the long follow-up.

PO-0169 Validation of the FACE-Q Head and Neck Cancer module: follow-up of a large Dutch multicenter cohort

D. de Jel 1,1 , D. Young-Afat 2 , H. Rakhorst 3,3 , R. Dirven 1 , R. Takes 4 , L. Smeele 1

1 Netherlands Cancer Institute - Antoni van Leeuwenhoek, Head and Neck Surgery, Amsterdam, The Netherlands; 2 Amsterdam University Medical Center, location VUmc, Plastic and Reconstructive Surgery, Amsterdam, The Netherlands; 3 Medisch Spectrum Twente, Plastic and Reconstructive Surgery, Enschede, The Netherlands; 4 Radboud University Medical Center, Head and Neck Surgery, Nijmegen, The Netherlands