ICHNO-ECHNO 2022 - Abstract Book

S19

ICHNO-ECHNO 2022

Proffered papers: Innovative highlights 3

OC-0033 The course of supportive care needs in HNC patients during 2 years follow-up and factors associated

D. Molenaar 1 , I. Verdonck-de Leeuw 1 , B. Lissenberg-Witte 2 , R. Brakenhoff 1 , R. Takes 3 , C. Terhaard 4 , H. Langendijk 5 , R. Baatenburg de Jong 6 , J. Smit 7 , R. Leemans 8 , F. Jansen 8 1 AmsterdamUMC, Location VUmc, Department of Otolaryngology/Head & Neck Surgery, Amsterdam, The Netherlands; 2 Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam, The Netherlands; 3 Radboud University Medical Center, Department of Otorhinolaryngology and Head and Neck Surgery, Nijmegen, The Netherlands; 4 University Medical Center Utrecht, Department of Radiotherapy, Utrecht, The Netherlands; 5 University of Groningen, University Medical Center Groningen, Department of Radiation Oncology, Groningen, The Netherlands; 6 Erasmus MC Cancer Institute, Department of Otolaryngology and Head and Neck Surgery, Rotterdam, The Netherlands; 7 AmsterdamUMC, Location VUmc, Department of Psychiatry, Neuroscience Campus Amsterdam and Amsterdam Public Health research institute, Amsterdam, The Netherlands; 8 AmsterdamUMC, Location VUmc, Department of Otolaryngology-Head and Neck Surgery, Amsterdam, The Netherlands Purpose or Objective The aim of this prospective cohort study was to investigate the longitudinal course of supportive care needs among HNC patients from pre-treatment to 2 years after treatment, and to investigate its associated sociodemographic, lifestyle, clinical, psychological, and symptom specific factors. Materials and Methods Patients with newly diagnosed HNC in 7 hospitals in the Netherlands were asked to participate in the Netherlands Quality of Life and Biomedical Cohort Study_Head and Neck Cancer (NET-QUBIC) between April 2014 and July 2018. Patients completed questionnaires at baseline(pre-treatment) and 3, 6, 12 and 24 months post-treatment. Besides the questionnaires, home visits, consisting of physical tests and interviews were conducted at baseline, 6, 12 and 24 months. Mixed model analyses were used to study the course of supportive care needs (as measured using the Supportive Care Needs Survey (SNCS-SF34) and the HNC-specific module (SCNS-HNC)) from baseline up to 2 years after treatment, and to identify factors associated with this course. Results 739 patients were included in NET-QUBIC, of which 563 patients filled in the SCNS-SF34/SCNS-HNC before start of treatment and were included in this study. At baseline the highest needs were on the health system, information and patient support domain (mean 30.2;SD 23.0), followed by the psychosocial support domain (mean 25.8; SD 24.1), the physical and daily living domain (mean 15.7; SD 20.8), the HNC specific functioning domain (mean 15.1; SD 17.5), HNC specific lifestyle domain (mean 13.4; SD 24.0) and sexuality domain (mean 12.3; SD 19.8). On all supportive care domains, except sexuality needs, supportive care needs significantly changed over time. Supportive care needs either improved (i.e. psychosocial and health system, information and patient support needs) or worsened (physical and daily living and sexuality) from baseline up to M3, after which it improved down to and below baseline levels. Sex, tumor site, smoking, fear of recurrence, oral pain, and appetite loss at baseline were independently associated with the course of physical and daily living needs; tumor site, fear of recurrence, seeking social support, emotional functioning, physical functioning, coughing, and the use of painkillers with the course of psychosocial needs and muscle strength with the course of health system, information and patient support needs. Tumor stage, tumor site, seeking social support, physical functioning, nausea and vomiting, and speech problems were related to the course of HNC specific needs and smoking and excessive alcohol use with lifestyle needs. Conclusion Supportive care needs decline over time. However, some patients still have high unmet needs at long-term follow-up. Sociodemographic, clinical, psychological, lifestyle and symptom specific factors appear to be associated with the course of supportive care needs. These factors might help to identify patients with supportive care needs and better tailor supportive care to their individual needs. 1 , , , United Kingdom; 2 The Christie NHS Foundation Trust, Clinical Oncology, Manchester, United Kingdom; 3 The University of Manchester, Division of Cancer Sciences, Manchester, United Kingdom Purpose or Objective There is a renewed interest in hypofractionated radiotherapy regimens for the treatment of head and neck cancer. In the UK a mildly accelerated, hypofractionated regimen over 6 weeks has been used for some time, although there is no comparative evidence with a standard fractionation schedule over 7 weeks. In this project we assessed survival and swallowing outcomes for patients with oropharynx squamous cell carcinoma (OPSCC) treated with three different definitive radiotherapy regimens. Materials and Methods A multi-centre, observational study of consecutive OPSCCs treated between 2015 and 2018 by curative-intent radiotherapy to the oropharynx and bilateral neck (n = 277) with a radiotherapy dose / fractionation regimen of either (i) 70 gray (Gy) in 35 fractions over 7 weeks (n = 97), (ii) 65-66 Gy in 30 fractions over 6 (n = 136) or (iii) 55 Gy in 20 fractions over 4 weeks (n = 39). Locoregional control (LRC) and overall survival (OS) were compared for all patients. Patients who were alive and cancer free were sent an MDADI questionnaire for completion; swallowing outcomes were compared. OC-0034 Survival and swallowing outcomes for standard and hypofractionated radiotherapy in oropharynx cancer Z. Iyizoba-Ebozue 1 , J. Price 2 , C. West 3 , D. Thomson 2