ICHNO-ECHNO 2022 - Abstract Book

S24

ICHNO-ECHNO 2022

Figure 2. Caregivers mean supportive care needs over time per SCNS-C&P45 subdomain.

Conclusion This prospective longitudinal cohort shows that HNC caregivers have high unmet supportive care needs. The unmet needs decrease during follow-up, but even two years after treatment nearly 30% of the caregivers report unmet needs. A high caregiver burden and reduced psychosocial functioning were predictive for more unmet needs during follow-up. Our results give valuable insights for the clinical practice, as we identified the most reported unmet needs in terms of content and needs at different time points, and established subgroups prone for more unmet needs.

Symposium: How to manage frail patients in the localised setting

SP-0039 Assessment of frail patients in daily practice Ceclie Mertens France

Abstract not available

SP-0040 Which concomitant treatment with radiotherapy for patients unfit for cisplatin Irene Brana Spain

Abstract not available

SP-0041 Long term quality of life in HN Cancer survivors

I. Verdonck-de Leeuw 1,2,3 , B.I. Lissenberg-Witted 4 , R.J. Baatenburg de Jong 4 , R.H. Brakenhoff 2,1 , J.A. Langendijk 5 , J.H. Smit 6 , R.P. Takesh 7 , C.H.J. Terhaard 8 , R. Leemans 2,1 , F. Jansen 9,1 1 Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam Research Institute, Amsterdam, The Netherlands; 2 Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Otolaryngology - Head and Neck Surgery, Amsterdam, The Netherlands; 3 Vrije Universiteit Amsterdam, Department of Clinical, Neuro- and Developmental Psychology, Faculty of Behavioral and Movement Sciences & Amsterdam Public Health Research Institute, Amsterdam, The Netherlands; 4 Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Epidemiology and Data Science, Amsterdam, The Netherlands; 5 University of Groningen, University Medical Center Groningen, Department of Radiation Oncology, Groningen, The Netherlands; 6 Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Department of Psychiatry, Amsterdam, The Netherlands; 7 Radboud University Medical Center, Department of Otorhinolaryngology and Head and Neck Surgery, Nijmegen, The Netherlands; 8 University Medical Center, Department of Radiotherapy, Utrecht, The Netherlands; 9 Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Otolaryngology - Head and Neck Surgery , Amsterdam, The Netherlands Abstract Text The NETherlands QUality of life and BIomedical Cohort study in head and neck cancer (HNC) (NET-QUBIC) is a prospective cohort study including 739 HNC patients and 262 informal caregivers. NET-QUBIC comprises a Data Warehouse and Biobank integrating detailed clinical information and data derived from patient reported outcomes, interviews, and functional tests, and samples of tumour tissue, blood, oral rinse, and saliva. Data and samples are available to researchers worldwide via data releases that are announced on www.kubusproject.nl. In the present study, we used NET-QUBIC data and samples to investigate the course of health related quality of life (HRQoL) of HNC patients from diagnosis to 3, 6, 12 and 24 months after treatment. HRQoL was operationalised by the EORTC QLQ- C30 global quality of life subscale (2 items) and the summary score. The summary score is based on five functional scales (physical, cognitive, emotional, social, and role functioning), three symptom scales (fatigue, nausea–vomiting, and pain), and five items (dyspnoea, insomnia, appetite loss, constipation, and diarrhoea). We hypothed that there is a significant change of HRQoL over time with worse scores from baseline to 3 months after treatment (the acute phase of HNC diagnosis and treatment), after which HRQoL improves and remains steady over time from 6 months to 2 years after treatment. We explored which personal, clinical, psychological, physical, social, and lifestyle factors, HNC symptoms, and biomarkers of stress and inflammation, as measured at baseline, are associated with the course