ICHNO-ECHNO 2022 - Abstract Book

S27

ICHNO-ECHNO 2022

1 N.N. Alexandrov National Cancer Center, Head and Neck oncology department, Minsk, Belarus; 2 N.N. Alexandrov National Cancer Cente, Cancer Control Organization Departmen, Minsk, Belarus Purpose or Objective Malignant tumors of the paranasal sinuses (PS) and the nasal cavity (NC) are a serious medical and social problem of modern clinical oncology. Tumors of the NC and PS account for 2-3% of head and neck tumors, with more than 70% of patients admitted for treatment in the later stages of the disease with locally common processes. The presence of a large number of patients in the advanced stages of the disease is explained by the latent course of the disease at early stages and late patient appeal ability, and there are no “high-risk groups” in the development of malignant tumors. Malignant tumors of the NC and PS facultative and obligate precancerous conditions are not clearly defined, respectively, the tactics of treatment of pretumor diseases until the end flax is not defined. Unlike head and neck tumors of other localizations, tumors of NC and PS are represented by various epithelial and non-epithelial morphological variants. Materials and Methods Analysis of medical records of 212 patients with malignant tumors of the PS and NC who received treatment at the N. N. Alexandrov National Cancer Centre from 1994 to 2018. Predicting factors for the development of malignant tumors were estimated, depending on the localization of the primary tumor and spreading into the various parts of the PS and NC. Results The predicting factors for the development of malignant tumors, depending on the localization of the primary tumor and spreading in to the various parts of the paranasal sinuses and nasal cavity were determined. Extension to the posterior wall of the maxillary sinus, orbit and base of the skull were unfavorable factors in assessing overall survival and were chosen by us to assess their impact on the development of tumor recurrence. With the primary spread of the tumor to the posterior wall of the maxillary sinus, 11 (78.6%) patients had a relapse of the disease, which is statistically significantly (p = 0.027) higher than in the group of patients without spread to this area - 61 (47.3%). With the primary spread of the tumor into the orbit, 23 (67.6%) patients had a relapse of the disease, which is statistically significantly (p = 0.021) higher than in the group of patients without spread to this area - 49 (49.9%). With the primary spread of the tumor on the skull base in 12 (75.0%) patients had a relapse of the disease, which is statistically significant (p = 0.033) higher than in the group of patients without spread to this area - 60 (47.2%). Conclusion Based on the data, obtained a list of factors for predicting the development of recurrence of malignant tumors was formed depending on the localization of the primary tumor, spread in various parts of the PS and NC: tumor spread to the base of the skull, tumor spread into the orbit, tumor spread to the posterior wall of the maxillary sinus.

PO-0057 Impact of socioeconomic factors and treatment on oral cancer survival in a population database.

H. Köhler 1 , J.G. Vartanian 1 , T. Chulam 1 , L.P. Kowalski 1

1 A C Camargo Cancer Center, Head and Neck Surgery and Otolaryngology, São Paulo, Brazil

Purpose or Objective To compare the results of upfront surgery and non-surgical therapies in resectable advanced oral squamous cell carcinoma. Materials and Methods We analyzed a hospital-based database from the state of São Paulo, Brazil. This database contains information on demographic, clinical, pathologic, treatment and outcomes of patients treated for cancer. We compared patients treated by upfront surgery and non-surgical approaches regarding the factors that impact treatment choice and oncologic outcomes. To minimize differences between the groups, we performed two subsets analysis based on cT stage and matched patients in a 1:1 ratio using propensity scores. Results We analyzed 9,050 patients, with 5,058 receiving surgery as part of treatment. Age, gender and cT and cN stage were unevenly distributed in the different treatment modalities. At last notice, 5,143 were dead from disease progression and 1,288 from other causes. Multivariate Cox model disclosed age, cT and cN stage and treatment modality as significant for disease-specific and overall survival. In the subset of patients with cT3 and cT4a primary tumors, we matched patients according to treatment received and surgically treated patients had improved survival outcomes compared to chemoradiation.

Conclusion Surgery should be employed as first treatment option in patients with oral squamous cell carcinoma.

PO-0058 Nasopharynx Cancer Epidemiological Profile Clinical Aspects And Therapeutic Modalities

H. Kamel 1

1 clcc Batna, Radiothérapy, Batna, Algeria

Purpose or Objective Evaluate the epidemiological, clinical, prognostic and therapeutic data of cancer