ICHNO-ECHNO 2022 - Abstract Book

S75

ICHNO-ECHNO 2022

SFUD treatment plans (lower row), where the high-LET d protons are more condensed. The LET d > 4 keV/um covers about 5% and 10% of the PTV volume for the IMPT and SFUD plans, respectively.

Conclusion While considering the variable RBE in proton radiotherapy, the use of the SFUD treatment plan optimization technique might lead to the regions of high LET d in comparison to IMPT plans and in consequence the higher RBE-weighted dose at the edges of radiation fields. It is particularly important when the tumor is surrounded by radiosensitive tissues where the high dose might cause side effects, such as brain necrosis. The risk of developing brain changes will be discussed in terms of the RBE-weighted dose and LET d distributions for both SFUD and IMPT approaches.

PO-0123 Survival outcomes on all head and neck cancer patients from a single MDT in the modern era

M. Kazi 1 , M.S. Iqbal 2 , J. O'Hara 3 , D. Hamilton 3 , M. Kennedy 3 , J. Adams 4 , A. McQueen 5 , O. Ahmed 6 , L. Warner 3 , A. Chambers 7 , L. Gradwell-Nelson 3 , H. Fox 3 1 Newcastle Upon Tyne Hospital, Otolaryngology , Newcastle upon Tyne, United Kingdom; 2 Newcastle Upon Tyne Hospital, Clinical Oncology, Newcastle Upon Tyne, United Kingdom; 3 Newcastle Upon Tyne Hospital, Otolaryngology, Newcastle Upon Tyne, United Kingdom; 4 Newcastle Upon Tyne Hospital, Maxillofacial surgery, Newcastle Upon Tyne, United Kingdom; 5 Newcastle Upon Tyne, Radiology, Newcastle Upon Tyne, United Kingdom; 6 Newcastle Upon Tyne Hospital, Plastic Surgery, Newcastle Upon Tyne, United Kingdom; 7 Newcastle Upon Tyne Hospital, Cellular Pathology, Newcastle Upon Tyne, United Kingdom Purpose or Objective Head and neck cancer is a heterogeneous group of subsites. In the UK, all newly diagnosed cancer patients are discussed in a multidisciplinary team and a management plan is agreed. The purpose of this study was to analyse the head and neck cancer patients’ demographics, disease characteristics and their survival outcomes who were diagnosed during the year 2015. Materials and Methods The data were collected retrospectively and all newly diagnosed patients were included in the study. The patients with non-head and neck pathology e.g. lymphoma, skin cancer of the head and neck regions and head and neck metastases from other primaries were excluded. Results There were a total of 172 patients with a median age of 66 years (range 31-93). Male to female ratio was 124:48. Larynx was the most frequent primary (29%), followed by oropharynx (26%), oral cavity (25%), hypopharynx (10%), sinonasal (3%) and others (7%). For larynx primary, 44 patients were treated with radical intent and 5 with palliative intent. For early stage disease (T1/2), 7 out of a total of 31 patients had died. For T3/4 or N+ disease, 8 out of 13 patients had died. For oropharyngeal primary, 28 patients were HPV positive, 14 were with HPV negative and in 5 cases, HPV status was unknown. 17 patients were treated with primary surgery ± adjuvant treatment, 24 with radical (chemo)radiotherapy and remaining 4 patients were treated with palliative intent. Only 3 HPV positive patients treated with radical intent had died as compared to 9 HPV negative patients. For oral cavity primary, 37 patients were treated with radical intent and 12 of these patients had died – 8 with recurrence and/or metastatic disease. For hypopharynx primary, 13 out of a total 17 patients were treated with radical intent and 7 of these had died with disease. For sinonasal primary, 4 out of a total 6 patients were treated with radical intent and 2 of these patients had died of disease. Overall, at the time of analysis (insert date), 102 patients were alive and remaining 70 had died with a 5 year overall survival of 59.3%. Five year disease specific survival for all patients was 72.7% and for those patients were treated with a radical intent, 5 year disease specific survival was 84.9%. Conclusion Though heterogeneous in nature, our study provides survival outcomes on head and neck cancer patients with a long-term follow-up. Documenting this information may be useful in developing future prospective studies and structure of service provision especially in view of head and neck cancer survivorship.

PO-0124 Does systemic therapy impact failure patterns in locally advanced laryngeal/hypopharyngeal cancer?

S. Koerner 1 , A. Keller 1 , D. Clump 1

1 UPMC Hillman Cancer Center, Radiation Oncology, Pittsburgh, USA

Purpose or Objective Standard of care for locally advanced malignancy of the larynx and hypopharynx is surgical resection with adjuvant radiotherapy (RT). However, many patients choose organ-preserving definitive RT due to significant morbidity associated with resection. Long term data regarding patterns of failure for patients treated definitively in the modern era is sparse,