IGRT 2016 Madrid

Dose escalation in 3D-CRT and late toxicity

GI

GU

MDACC 70Gy 78Gy

13%(10-y) 26% G2+ (10-y)

8% (10-y) 13% (10-y)

MRC RT 01 64Gy 74Gy CVKO 9610 68Gy 78Gy

24%(5-y) 33% (5-y)

8% (5-y) 11% (5-y)

27%(5-y) 32% (5-y)

41% (5-y) 39% (5-y)

PROG 70.2Gy 79.2CGE

8% (5-y) 10% (5-y)

18% (5-y) 20% (5-y)