IGRT 2016 Madrid

Daily IG-IMRT and reduced PTV margin in clinical practice

Biochemical Progression-free Survival

0.00 0.25 0.50 0.75 1.00 Survival(%)

• 2001-2007

• Daily IG-IMRT

• Median dose 78 Gy (74-78Gy @ 2Gy/fx)

5 mm 10 mm

Logrank test : p=0.576

0 6 12 18 24 30 36 42 48 54 60 66 72 Months

5 mm N at risk

• 165 pts • PTV margin10mm (n= 78) vs. 5mm (n= 87) • Median FU = 39 months

83 81 81 76 64 58 46 28 24 22 19 13 8 87 86 85 79 63 56 44 36 30 19 14 5 3

10 mm

• GI : G2 = 1.2% (5mm) vs. 2.6% (10mm) , p = NS • NoG3+

Créhange G. et al., Radiother Oncol 2012