IMRT Course 2016

Late toxicity after 3D conformal radiotherapy

Late toxicity and limb function are related to treatment volumes and RT dose Soft tissue fibrosis Lymphoedema Bone fractures, joint stiffness Rates of ≥grade 2 fibrosis in 48.2% with post-operative RT Davis et al. Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. Radiotherapy and Oncology 2005, 75:48–53.

Negative impact on function

8

50 Gy/25# pre-op

66 Gy/33# post-op