IMRT Course 2016

IMRT prospective clinical trials 2

Preoperative IGRT 50Gy in 25 fractions prior to surgery IGRT used in order to reduce target volumes Primary endpoint: 15% absolute improvement in rate of grade ≥2 radiation morbidity (subcutaneous tissue fibrosis, joint stiffness, oedema) at 2 years, from 37% to 22% 79 patients (2008 – 2010) Could receive IMRT (74.7%) or 3DCRT (25.3%) Results: 5/74 (7%) local recurrences (all in field) 57 patients assessed for late toxicity – 10.5% experienced at least one grade ≥2 toxicity (vs 37% in SR2 trial) p<0.001 Conclusion: The significant reduction in late toxicities, and absence of marginal recurrences suggest that the reduced volumes used were appropriate

Wang et al Journal of Clinical Oncology 2015 Jul 10;33(20):2231-8. doi: 10.1200/JCO.2014.58.5828. Epub 2015 Feb 9.

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