IMRT

3-years GU (G2-3) toxicities correlated with both high and “low” dose if empty bladder ( Harsolia, IJROBP, 2007)

V30Gy < 33.5 cc 2% G3 V30Gy > 33.5 cc 20% G3

V82Gy < 2.5 cc 2% G3 V82Gy > 2.5 cc 12% G3 8 years GU (G1-3) toxicities correlated with “ hottest volume ”

V78Gy < 2.9 % 25 % 8-years risk V78Gy > 2.9 % 50 % 8-years risk