IMRT

Black: pts with tox Grey: pts without tox UVA: V15 best predictor compared to V40- V50…..due to larger differences at low doses (geometry…no biology !!!!)

1000,0 1200,0 1400,0 1600,0 1800,0

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0,0 200,0 400,0 600,0 800,0

0,0 10,0 20,0 30,0 40,0 50,0 60,0 Gy

V15 AS A SURROGATE OF THE HIGH-DOSE REGION IN THE BOX TECHNIQUE NO BIOLOGICAL MEANING - DONT USE IT (ALONE) IN IMRT OPTIMIZATION…