IMRT

Pattern of failure following SBRT

Local 4.9%

Regional

Distant 14.7%

Actuarial 2-year rates

7.8%

Actuarial 5-year rates

10.5%

12.7%

19.9%

Median time to event

Local recurrence

14.9 months (95% CI 11.4-18.4) 13.1 months (95% CI 7.9-18.3) 9.6 months (95% CI 6.8-12.4) 18 months (95% CI 12.5-23.5)

Regional recurrence Distant recurrence 2nd primary tumors

• Stage I-II NSCLC (2003-2011); median follow-up 32.9 months (IQR 14.9 - 50.9); • 66% of recurrences were distant (DR); isolated DR made up 46% of recurrences