IMRT

UZ Brussel approach

 Alternative strategy UZ Brussel: IG-IMRT + simultaneous integrated boost (SIB) by helical tomotherapy

 To decrease the toxicity  by reducing the irradiated volumes of small bowel and bladder by IG-IMRT  by omitting concomitant 5-FU chemotherapy  To maintain the oncological safety  by delivery of a simultaneous integrated boost to bad T3 (CRM ≤ 2mm) and T4 tumors

 Phase II Study: primary endpoint 2-year local control

 ≤ 3/100 patients with local failure

De Ridder and Engels et al, Int J Radiat Oncol Biol Phys and Radiother Oncol 2008 - 2014

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