IMRT

Clinical relevance of the serial cost function

1

N

1

N ∑ = 1 i

1 = ∑ = N i

k

1 ,

F

≥ k D

k

D

EUD

directly related to…

=

k

serial

i

serial

i

N

For rectal complications (grade>=2 bleeding) strong clinical evidence, that NTCP is clearly related to rectal EUD!

k = ~13.5

M. Söhn et al. 2007 (IJROBP 67(4)) Quantec-Report: J. M. Michalski et al. 2010 (IJROBP 76(3))

EUD serial

[Gy]

ESTRO IMRT course 2015 IMRT optimization: algorithms&cost functions Brussels October 5th, 2015

-64-