IMRT

This was all offline ART… Now: Online Adaptive Re-Planning

Ghilezan et al. 2004 (IJROBP 60(5))

Fx 1

Fx 2

Fx N

…

CT

CT

CT

IMRT plan

IMRT plan

IMRT plan

no margin!

Results (in short): • average dose escalation by 13% possible, but with large interpatient variation (5-41%). • 27% of the patient would have only minimal benefit (<5% dose escalation), 32% would have significant benefit (>15% dose esc.) Note!: • comparison relative to non adaptive standard IMRT (1 cm margin), not to offline adaptive IMRT. • no margin, intrafraction motion and all other uncertainties neglected

ESTRO IMRT course 2015 Adaptive Radiotherapy Brussels October 8th, 2015

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