IMRT

Second Cancers: IMRT vs. 3D-CRT

Key is the shape of the dose-response relationship for radiation-induced carcinogenesis... High doses don ’ t matter

High doses do matter

OR

Cancer Risk

total dose

total dose

• IMRT minimizing high doses helps • IMRT ’ s extra lower doses less important

• IMRT minimizing high doses doesn ’ t help • IMRT ’ s extra lower doses are bad